STAT!Ref Supplemental Updates

ACP PIER & AHFS DI® Essentials™ ©2009

©2009 ACP PIER: American College of Physicians

©2009 AHFS DI® Essentials™

Authors/Editors: ACP PIER: American College of Physicians (ACP) © 2009 by the American College of Physicians

PIER© is a collection of over 490 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care. Important features of PIER include:

•Truly evidenced-based

•Defines the current standard of care

•Frequently updated (Monthly Content Updates and Module Additions)

•Consistently structured for rapid access

•Search or browse by organ system

•Integrated drug reference (AHFS DI Essentials)

Topics are selected by ACP based upon prevalence in clinical settings. Evidence is then gathered by literature review and evaluated based on formal criteria. The level of evidence for each recommendation is displayed clearly within the application. PIER also includes topics in complementary and alternative medicine, ethical and legal issues, and procedures. Pediatric modules are now included.

AHFS DI® Essentials™ by the American Society of Health-System Pharmacists® (ASHP) is designed to offer health professionals easy access to knowledge that is critical at the point of care. Essentials™ monographs draw on the meticulously evidence-based guidelines in the full AHFS DI® database, distilling for the health professional the essential information on prescription and key over-the-counter (OTC) drugs in an easy-to-use, highly structured outline format.

•Comparative pricing for most Rx and OTC monographs.

•'Compatibility' sub-heading under the ‘Stability’ section within a monograph features Admixture and Y-Site and is perfect for nurses who administer drugs.

•Essentials™ includes a subset of drugs from the full AHFS DI® database. Drugs were selected from those most widely used in hospital (including most parenteral drugs) and outpatient (including key OTC products) settings, new molecular entities (NMEs) introduced into the US market over the past 6 years, and drugs requiring particular attention for safe use (e.g., those with boxed warnings).

What's New in October 2009

UPDATED MODULES:

Advance Care Planning

Arterial Blood Gases

Asthma in Pregnancy

Autoimmune Hepatitis Carotid

Artery Stenosis

Chronic Fatigue Syndrome

Chronic Pancreatitis

Electrocardiogram

Esophageal Cancer

Fibromyalgia Syndrome

Hemophilia

Hepatitis A

Hepatitis B

Hypercalcemia

LASIK Eye Surgery

Lipid Disorders (Dyslipidemia)

Nodular Thyroid Disease

Osteoarthritis

Parvovirus B19 Infection and Fifth Disease

Perioperative Evaluation of Patients with Liver Disease

Pleurisy

Preoperative Cardiac Risk Assessment

Prevention of Unintended Pregnancy

Rosacea

Salicylate Poisoning Screening for Lung Cancer

Systemic Lupus Erythematosus

Vulvar Cancer

Vulvodynia (Vulvar Pain)

ACP PIER, Journal Club & AHFS DI® Essentials™

©2009 by the American College of Physicians

Authors/Editors: American College of Physicians (ACP)

A pre-appraised, evidence-based clinical tool that defines the standard of care, including value-added abstracts of original journal articles and drug treatment information.

PIER (Physicians' Information and Education Resource)

•Integrated and authoritative EBM resources for the point-of-care and background reference.

•Links in PIER's disease modules take users to supporting articles in ACPJC.

•Updated Monthly

•Combined with AHFS Essentials, the drug resource that provides quick access to dosage, interaction and other pharmacy information.

ACPJC

•ACP Journal Club is the quintessential EBM journal that summarizes original research applicable to clinical cases.

•Over 100 journals are reviewed for implications on therapeutics, diagnosis, prognosis and etiology.

 •McMaster Online Rating of Evidence (MORE) gathers ratings of new articles, already assessed for scientific merit, from sentinel readers (a panel of 2000+ physicians from around the world).

AHFS® DI Essentials™

•Distills the essential information from the larger AHFS Drug Information database.

•Comparative pricing for most Rx and OTC monographs.

AHFS DI® Essentials™

©2009 by the American Society of Health-System Pharmacists, Inc.

Authors/Editors: Gerald K. McEvoy, Pharm.D.

AHFS DI® Essentials™ offers healthcare professionals easy access to knowledge that is critical at the point of care. Essentials™ monographs draw on the meticulously evidence-based guidelines in the full AHFS DI® database, distilling essential information on prescription and key over-the-counter (OTC) drugs in an easy-to-use and highly structured outline format.

Comparative pricing for most Rx and OTC monographs.

What's New in November 2009:

New Monographs:

• Polymyxin B Antibacterial; polymyxin antibiotic structurally and pharmacologically related to colistin.

Revised Monographs:

• Amantadine: Antiviral; antiparkinsonian agent; adamantane derivative.
• Cefazolin: Antibacterial; b-lactam antibiotic; first generation cephalosporin.
• Cefotetan: Antibacterial; b-lactam antibiotic; cephamycin.
• Ceftriaxone: Antibacterial; b-lactam antibiotic; third generation cephalosporin.
• Emtricitabine: Antiretroviral; nucleoside reverse transcriptase inhibitor (NRTI).
• Entecavir: Antiviral; purine nucleoside analog derived from guanine.
• Etravirine: Antiretroviral; nonnucleoside reverse transcriptase inhibitor (NNRTI).
• Exenatide: Antidiabetic agent; synthetic glucagon-like peptide-1 (GLP-1) mimetic (incretin mimetic).
• Ezetimibe: Antilipemic agent; cholesterol absorption inhibitor.
• Heparin: Anticoagulant; a heterogeneous group of anionic, sulfated glycosaminoglycans.
• Iron Dextran: Ferric hydroxide in a complex with partially hydrolyzed low molecular weight dextran.
• Omeprazole: Acid- or proton-pump inhibitor; gastric antisecretory agent.
• Oseltamivir: Antiviral; neuraminidase inhibitor; sialic acid analog.
• Pantoprazole: Acid- or proton-pump inhibitor; gastric antisecretory agent.
• Raltegravir: Antiretroviral; HIV integrase inhibitor.
• Rimantadine: Antiviral; adamantane derivative.
• Rituximab: Antineoplastic agent; a chimeric human-murine anti-human antigen CD20 monoclonal antibody.
• Simvastatin: Antilipemic agent; hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor (i.e., statin).
• Zanamivir: Antiviral; neuraminidase inhibitor; sialic acid analog.

AHFS Drug Information®

©2009 American Society of Health-System Pharmacists

Authors/Editors: Gerald K. McEvoy, Pharm.D. and Elaine K. Snow, B.S. Pharm.

With the 2009 edition, the American Hospital Formulary Service® (AHFS™) marks over 50 years of continuous publication by the American Society of Health-System Pharmacists (ASHP). Each year, an average of over 60% of AHFS content is revised to help you provide the most accurate recommendations for your patients’ drug therapy. AHFS references are evidence-based and peer-reviewed, compiled without the influence of manufacturers, insurers, regulators or other interested parties. No other drug information sources can make this claim. AHFS DI has been designated as an official compendium by the US Congress. AHFS DI contains information from medical literature and expert advice from over 500 medical scientists, physicians, pharmacists, pharmacologists and other professionally qualified individuals that goes beyond FDA-approved labeling.

What's New in November 2009-Revised Monographs:

• Amantadine
• Antihistamines General Statement
• Antiretroviral Agents General Statement
• Cefazolin
• Cefotetan
• Cefoxitin
• Ceftriaxone
• Emtricitabine
• Entecavir
• Etravirine
• Exenatide
• Heparin
• Iron Dextran
• Omeprazole
• Oseltamivir
• Pantoprazole
• Polymyxin B
• Promethazine
• Raltegravir
• Rimantadine
• Rituximab
• Tetracyclines General Statement
• Zanamivir

APhA DrugInfoLine®

©2009 American Pharmacists Association (APhA)

Authors/Editors: L. Michael Posey

APhA DrugInfoLine® is a monthly newsletter of interpreted drug and pharmacotherapeutic information designed to keep frontline pharmacists current on the latest trends in the biomedical literature.

It includes regular coverage of these areas:

• Cardiology • Psychiatry • HIV Care • Endocrinology • Pulmonology • Immunizations • Gastroenterology • Rheumatology • Lipids Management • Infectious Diseases • Anticoagulation Care • Alternative Medicines • Neurology • Asthma Care • OTC Medications • Oncology • Diabetes Care • Drug Interactions

Each issue includes a "Medication Monitor," a table that summarizes new drug approvals.

What's New: September/October 2009, Vol. 10, No. 9/10

• Focus On: HIV Care - Betty J. Dong, Section Advisor
• Focus On: Immunizations - John D. Grabenstein, Section Advisor
• Drug Interactions Corner - Daniel S. Streetman, Section Advisor
• Psychiatric Disorders - M. Lynn Crismon, Section Advisor
• Focus On: Asthma Care - Devra K. Dang, Section Advisor
• Cardiovascular Disorders - Omar Badawi, Section Advisor
• Gastroenterologic Disorders - C. Wayne Weart, Section Advisor
• Alternative Medicines Corner - Nicole M. Maisch, Section Advisor
• Medication Monitor: Updates On Advances In Therapy

New Title, New Edition and Supplemental Updates: What's New in September 2009

New Titles:

Trauma Care: Initial Assessment and Management in the Emergency Department

©2008 Wiley-Blackwell

The often complex problems of the trauma patient present many challenges to front line emergency staff. Multiple injuries involving many systems of the body require careful and timely prioritization and intervention in the emergency department. Trauma Care provides emergency nurses with a practical guide to the systematic assessment and management of trauma patients, equipping them with the clinical knowledge and practical skills necessary to initially assess and care for the trauma patient in the emergency department trauma environment.

Atlas of Gastrointestinal Surgery, Vol. 1

2nd Edition ©2007 People's Medical Publishing House, USA

This is a beautiful, color surgical atlas, which will complete any surgeon's online library. The first edition was published 14 years ago, and this new edition reflects advances in surgical care, as well as improved illustrations and text.

The authors are authoritative leaders in surgery from the Johns Hopkins Hospital. The title describes the operative techniques on the foregut employed at this august institution. Many of the operations described were developed at Johns Hopkins. The atlas vividly depicts in color illustrations and clear language these surgical techniques, bringing them alive for the reader.

New Edition:

Ganong's Review of Medical Physiology

23rd Ed. ©2010 McGraw Hill Companies, Inc.

The field's most complete, current and engagingly written title on medical physiology -- now in full color. For more than four decades, Ganong's Review of Medical Physiology has been the leader in helping medical students and clinicians understand the fascinating subject of human and mammalian physiology. Concisely covering every important topic without sacrificing depth or readability, Ganong's delivers more detailed, clinically relevant, high-yield information per page than any similar title or review.

Supplemental Updates:

AHFS DI® Essentials™

©2009 by the American Society of Health-System Pharmacists, Inc.

AHFS DI® Essentials™ offers healthcare professionals easy access to knowledge that is critical at the point of care. Essentials™ monographs draw on the meticulously evidence-based guidelines in the full AHFS DI® database, distilling essential information on prescription and key over-the-counter (OTC) drugs in an easy-to-use and highly structured outline format.

ACP PIER, Journal Club & AHFS DI® Essentials™

©2009 by the American College of Physicians

A pre-appraised, evidence-based clinical tool that defines the standard of care, including value-added abstracts of original journal articles and drug treatment information.

•PIER (Physicians' Information and Education Resource) Integrated and authoritative EBM resources for the point-of-care and background reference.

•ACP Journal Club is the quintessential EBM journal that summarizes original research applicable to clinical cases.

•AHFS® DI Essentials™ distills the essential information from the larger AHFS Drug Information database.

ACP PIER & AHFS DI® Essentials™

©2009 ACP PIER: American College of Physicians

©2009 AHFS DI® Essentials™

PIER© is a collection of over 400 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care.

ACP PIER®: Physicians' Information and Education Resource

©2009 ACP PIER: American College of Physicians

PIER© is a collection of over 400 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care.

 

AHFS Drug Information®

©2009 American Society of Health-System Pharmacists

With the 2009 edition, the American Hospital Formulary Service® (AHFS™) marks over 50 years of continuous publication by the American Society of Health-System Pharmacists (ASHP). Each year, an average of over 60% of AHFS content is revised to help you provide the most accurate recommendations for your patients’ drug therapy.

 

Medical Letter® On Drugs and Therapeutics, The

©2009-1995 The Medical Letter, Inc.

The Medical Letter on Drugs and Therapeutics is an independent, nonprofit publication that offers unbiased critical evaluations of drugs for physicians and other members of the health professions. This resource evaluates virtually all new drugs and also reviews older drugs when important new information becomes available on their usefulness or adverse effects.

APhA DrugInfoLine®

©2009 American Pharmacists Association (APhA)

APhA DrugInfoLine® is a monthly newsletter of interpreted drug and pharmacotherapeutic information designed to keep frontline pharmacists current on the latest trends in the biomedical literature.

New Titles, New Edition and Supplemental Updates: August 2009

New Titles:

The Official Guide for Foreign-Educated Nurses: What You Need to Know about Nursing and Health Care in the United States

©2009 Springer Publishing Company

This title is the only guide to the United States health care system for nurses immigrating to this country as well as foreign-educated nurses who are already here.

 

Comprehensive Nursing Care for Parkinson's Disease

©2007 Springer Publishing Company

The incidence of Parkinson's is growing as the number of older adults making up the general population increases. The demand for nurses who specialize in the care of patients with movement disorders is also increasing and it is crucial that they have a comprehensive manual for patient care.

 

New Edition:

Clinical Neuroanatomy 26th Ed.

©2010 McGraw-Hill Companies, Inc.

Learn the essential aspects of neuroanatomy and its clinical relevance with the field's most concise, trusted and effective title.

 

 

Supplemental Updates:

ACP Journal Club

©2009 by the American College of Physicians

ACP Journal Club, published by the American College of Physicians, is the quintessential EBM journal, and is often positioned near the top of the EBM pyramid.

ACP Medicine

©2009 BC Decker

ACP Medicine is the first comprehensive reference to carry the name of the American College of Physicians. Developed to help busy physicians keep up with changing guidelines in primary care, ACP Medicine is a continually updated, evidence-based reference of internal medicine.

ACP PIER, Journal Club & AHFS DI® Essentials™

©2009 by the American College of Physicians

A pre-appraised, evidence-based clinical tool that defines the standard of care, including value-added abstracts of original journal articles and drug treatment information.

•PIER (Physicians' Information and Education Resource) Integrated and authoritative EBM resources for the point-of-care and background reference.

•ACP Journal Club is the quintessential EBM journal that summarizes original research applicable to clinical cases.

•AHFS® DI Essentials™ distills the essential information from the larger AHFS Drug Information database.

ACP PIER & AHFS DI® Essentials™

©2009 ACP PIER: American College of Physicians

©2009 AHFS DI® Essentials™

PIER© is a collection of over 400 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care.

ACP PIER®: Physicians' Information and Education Resource

©2009 ACP PIER: American College of Physicians

PIER© is a collection of over 400 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care.

ACS Surgery: Principles and Practice

©2009 B.C. Decker

Published by B.C. Decker in collaboration with the American College of Surgeons (ACS), this continually updated reference, noted for its problem solving approach and numerous illustrations, is geared to the surgeon in practice. Master surgeons outline their preferred core general surgical procedure techniques.

AHFS Drug Information®

©2009 American Society of Health-System Pharmacists

With the 2009 edition, the American Hospital Formulary Service® (AHFS™) marks over 50 years of continuous publication by the American Society of Health-System Pharmacists (ASHP). Each year, an average of over 60% of AHFS content is revised to help you provide the most accurate recommendations for your patients’ drug therapy.

AHFS DI® Essentials™

©2009 by the American Society of Health-System Pharmacists, Inc.

AHFS DI® Essentials™ offers healthcare professionals easy access to knowledge that is critical at the point of care. Essentials™ monographs draw on the meticulously evidence-based guidelines in the full AHFS DI® database, distilling essential information on prescription and key over-the-counter (OTC) drugs in an easy-to-use and highly structured outline format

 

INFECTIOUS DISEASES: The Clinician's Guide to Diagnosis, Treatment, and Prevention

©2007 WebMD Inc.

This resource, derived from ACP Medicine, provides practical guidance on a wide range of infectious diseases such as upper respiratory infections, STDs and meningitis as well as viral, bacterial and fungal infections. It includes more than 4,000 focused, practical and current recommendations in addition to halftone and color illustrations.

Medical Letter® On Drugs and Therapeutics, The

©2009-1995 The Medical Letter, Inc.

The Medical Letter on Drugs and Therapeutics is an independent, nonprofit publication that offers unbiased critical evaluations of drugs for physicians and other members of the health professions. This resource evaluates virtually all new drugs and also reviews older drugs when important new information becomes available on their usefulness or adverse effects. It is only available to single users online and covers the period from 1995-2008.*

AHFS Drug Information: What's New in April 2009

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2009)

New Monographs:
None

 

Revised Monographs:

a1-Proteinase Inhibitor: a1-Proteinase inhibitor is a naturally occurring inhibitor of serine proteases such as neutrophil elastase; this enzyme aids in the proteolytic destruction of the alveolar walls and connective tissue framework of the lung parenchyma.

Antihemophilic Factor (Human): Antihemophilic factor (human) is a preparation of antihemophilic factor (blood coagulation factor VIII) prepared from pooled human venous plasma obtained from suitable whole-blood donors.

Antineoplastic Agents General Statement: The pharmacology of antineoplastic agents is complex. Most of the useful chemotherapeutic agents appear to exert their effects on enzymes or on substrates acted upon by enzyme systems that are involved in DNA synthesis or function. Therefore, cells in the mitotic cycle (i.e., proliferating cells) are the most susceptible to the drugs. Although the drugs have some degree of specificity for malignant cells as a result of differences in characteristics of these specific cells, other rapidly proliferating tissues such as bone marrow, gastrointestinal epithelium, skin, hair follicles, germinal epithelium of gonads, and embryonic structures may also be affected.

AHFS Drug Information: What's New in March, 2009

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2009)

New Monographs:

• None

Revised Monographs:

• Botulinum Toxin: Botulinum toxin disrupts neurotransmission by inhibiting release of acetylcholine at cholinergic nerve terminals of the peripheral nervous system and at ganglionic nerve terminals of the autonomic nervous system, inducing a chemical denervation and flaccid paralysis and inhibiting glandular secretion.
• Efalizumab: Efalizumab, a recombinant humanized anti-CD11a monoclonal antibody, is an immunosuppressive agent.
• Immunization Schedules: The recommended US immunization schedules for children 0 through 6 years of age, children and adolescents 7 through 18 years of age, and adults 19 years of age or older that are in effect for 2009.
• Metoclopramide: Metoclopramide hydrochloride is a dopamine-receptor antagonist, an antiemetic, and a stimulant of upper GI motility (prokinetic agent).
• Mycophenolate: Mycophenolate mofetil and mycophenolate sodium are used as immunosuppressive agents.
• Prilocaine: Prilocaine hydrochloride is an intermediate-acting local anesthetic of the amide type.
• Tetracaine: Tetracaine hydrochloride is a local anesthetic.
• Tetracaine: Tetracaine hydrochloride is a long-acting local anesthetic of the ester type.
• Zonisamide: Zonisamide is used in combination with other anticonvulsants in the management of partial seizures in adults with epilepsy.

AHFS Drug Information 2009

AHFS Drug Information® 2009
Author: Gerald K. McEvoy, Pharm.D
American Society of Health-System Pharmacists (ASHP)
50th Edition (2009)

With the 2009 edition, the American Hospital Formulary Service® (AHFS™) marks over 50 years of continuous publication by the American Society of Health-System Pharmacists (ASHP). Each year, an average of over 60% of AHFS content is revised to help you provide the most accurate recommendations for your patients’ drug therapy.

AHFS references are evidence-based and peer-reviewed, compiled without the influence of manufacturers, insurers, regulators or other interested parties. AHFS DI contains information from medical literature and expert advice from over 500 medical scientists, physicians, pharmacists, pharmacologists and other professionally qualified individuals that goes beyond FDA-approved labeling.

Inside find:

• Expanded and revised content for 2009, including many new monographs
• Extensive off-label uses.
• Expert advice and peer reviewed by over 500 medical scientists, physicians, pharmacists, pharmacologists and other professionally qualified individuals

AHFS Drug Information®: What's New in February, 2009

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2008)

New Monographs:

• Alvimopan: Alvimopan is a peripherally acting μ-opiate receptor antagonist.
• Anagrelide: Anagrelide is an imidazoquinazoline-derivative platelet-reducing agent.
• Bismuth Salts: Bismuth subsalicylate is an antidiarrheal agent and antidyspepsia agent; bismuth subgallate is an internal deodorant.
• Cabergoline: Cabergoline is an ergot-derivative dopamine receptor agonist and prolactin inhibitor.
• Ciclesonide (EENT): Ciclesonide is a synthetic, nonhalogenated corticosteroid that has glucocorticoid activity.
• Ciclesonide: Ciclesonide is a nonhalogenated glucocorticoid.
• Cisatracurium: Cisatracurium, a nondepolarizing neuromuscular blocking agent, is an isomer of atracurium.
• Fibrin Sealant: Fibrin sealant, a combination of 2 components (sealer protein concentrate [human] and thrombin [human]) derived from pooled human plasma, mimics the final stage of the blood coagulation cascade.

AHFS Drug Information: What's New in December, 2008

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2008)

New Monographs:

• Clevidipine: Clevidipine is a 1,4-dihydropyridine-derivative calcium-channel blocking agent.
• Difluprednate: Difluprednate is a difluorinated corticosteroid.
• Protein C Concentrate: Protein C, a naturally occurring precursor of a vitamin K-dependent serine protease, is an anticoagulant.
• Romiplostim: Romiplostim, a biosynthetic (recombinant DNA-derived) Fc-peptide fusion protein, is a thrombopoietin receptor agonist.

Revised Monographs:

• Adefovir: Adefovir dipivoxil is a prodrug of adefovir, an acyclic nucleotide analog antiviral agent that is active against human hepatitis B virus (HBV) and certain other viruses.
• Aldesleukin: Aldesleukin, a human interleukin-2 derivative, is a biosynthetic (recombinant DNA origin) cytokine (i.e., lymphokine) with antineoplastic and immunomodulating activities.
• Alemtuzumab: Alemtuzumab, a recombinant DNA-derived humanized anti-CD52 monoclonal antibody (Campath-1H), is an antineoplastic agent.
• Alteplase: Alteplase, a biosynthetic (recombinant DNA origin) form of the enzyme human tissue-type plasminogen activator (t-PA), is a thrombolytic agent.

AHFS Drug Information: What's New in October 2008

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2008)

New Monographs:

• Bendamustine: Bendamustine, a bifunctional mechlorethamine-derivative alkylating agent and purine analog, is an antineoplastic agent.
• Nebivolol: Nebivolol is a β1-selective adrenergic blocking agent.

Revised Monographs:

• Adalimumab: Adalimumab, a recombinant DNA-derived human immunoglobulin G1 (IgG1) monoclonal antibody specific for human tumor necrosis factor (TNF; TNF-α), is a biologic response modifier and is a disease-modifying antirheumatic drug (DMARD).
• Atomoxetine: Atomoxetine is a selective norepinephrine-reuptake inhibitor.
• Diclofenac: Diclofenac is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) that also exhibits analgesic and antipyretic activity.
• Enfuvirtide: Enfuvirtide, a synthetic antiretroviral agent, is a human immunodeficiency virus (HIV) fusion inhibitor.

AHFS Drug Information: What's New in September 2008

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2008)

This Doody's Core Title selection includes thousands of point-by-point revisions and critical updates to help you provide the most accurate recommendations for your patients’ drug therapy. AHFS references are evidence-based and peer-reviewed, compiled without the influence of manufacturers, insurers, regulators or other interested parties. The only printed drug reference that has been designated as an official compendium by the U.S. Congress, AHFS DI contains information from medical literature and expert advice from over 500 medical scientists, physicians, pharmacists and pharmacologists that goes beyond FDA-approved labeling.

New Monograph:

• Sapropterin: Sapropterin dihydrochloride is the synthetic dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), a cofactor in the metabolism of phenylalanine. 

Revised Monographs:

• Amiodarone: Amiodarone hydrochloride is considered to be predominantly a class III antiarrhythmic agent, but the drug also appears to exhibit activity in each of the 4 Vaughn-Williams antiarrhythmic classes, including some class I (membrane-stabilizing) antiarrhythmic action.
• Aspirin: Aspirin (the prototype of the salicylates) is a nonsteroidal anti-inflammatory agent (NSAIA) and also exhibits antithrombotic, analgesic; and antipyretic activity.