Applied Biopharmaceutics & Pharmacokinetics

5th Ed. ©2005 McGraw Hill Publishers Inc.

Authors/Editors: Leon Shargel PhD, RPh, Susanna Wu-Pong PhD, RPh & Andrew B.C. Yu PhD, RPh

 

The Best Way to Learn Biopharmaceutics and Pharmacokinetics. Applied Biopharmaceutics and Pharmacokinetics provides the reader with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. The revised and updated fifth edition of this popular text remains unique in teaching the student the basic concepts that may be applied to understanding the complex issues associated with the processes of drug delivery and the essentials of safe and effective drug therapy. New to this Edition: Chapter on Pharmacogenetics Explanation of the role of pharmacogenetics in drug metabolism using examples of drugs that frequently lead to drug interactions Chapter on the Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy Enhanced applications to pharmacy practice with the emphasis on biopharmaceutics, pharmacokinetics and drug delivery Updated coverage of dosing in clinical situations including dosing in special populations and what to do with a skipped dose in patients Additional practice problems and clinical examples Newest concepts in biopharmaceutics and pharmacokinetics Reorganized content to follow today's curriculum in pharmaceutical sciences

Supporting Resource:

The Biochemical Basis of Neuropharmacology 8th Ed. ©2003 Oxford University Press

This classic text covers the basics of neurotransmitters, receptors, neurochemical brain systems and drug action in psychiatric illness. It features clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain and the growing recognition of nicotine receptors in the brain and their possible involvement in Alzheimer’s and Parkinson's diseases. Written and edited by internationally recognized experts in the field, this resource continues to be an enormous contribution to education in the neurosciences.

New Title: Textbook of Regional Anesthesia and Acute Pain Management

Textbook of Regional Anesthesia and Acute Pain Management

©2007 McGraw Hill Publishers, Inc. Authors/Editors: Admir Hadzic MD, PhD

Perioperative Care Table of Contents Overview The single most comprehensive hands-on guide to the practice of Regional Anesthesia and Pain Management--in full color! Here at last is a reference that covers the practice of Regional Anesthesia in its entirety, providing practitioners and students with both the physiologic principles and specific, state-of-the-art patient-management protocols and techniques. Recognized leaders in the specialty have filled this richly illustrated volume with authoritative, completely practical help. You'll find algorithms for managing or avoiding a wide range of common clinical dilemmas or complications. You'll get time saving tools such as intravenous-to-oral opioid conversion tables and PCA setup guides as well as no-nonsense selection of nerve block techniques and advice on their strengths and pitfalls. This handy reference helps you make wise choices about anesthetics, dosing intervals, equipment and perioperative management of patients receiving single-injection or continuous nerve blocks or spinal or epidural anesthesia. It tells you how to successfully manage patients with suspected epidural hematoma or neurologic injuries and much more. Filled with full-color, high-quality, detailed illustrations and clinical images of actual patients Covers the entire field of regional anesthesia, including nerve stimulator and ultrasound-guided peripheral nerve blocks, from imaging and instrumentation to step-by-step instructions for employing them in adults and children Details how to achieve reliable anesthesia and analgesia for surgical interventions on the face and upper and lower extremities Provides information on the advantages and disadvantages of using regional anesthesia in patients with coexisting diseases Offers guidance on acute pain management of adults and children in the perioperative period and in the ER Features current information on the etiology, prevention and management of a wide range of complications

Supporting Resource:

Clinical Anesthesiology 4th Ed. ©2006 McGraw Hill Publishers Inc.

This title integrates succinct coverage of basic principles and clinical considerations in the anesthetic management of patients. It features up-to-date discussion of all relevant areas within anesthesiology, including equipment, pharmacology, regional anesthesia, pathophysiology, pain management, anesthetic management, and critical care. Extensive use of case discussions, figures, and tables in each chapter promotes application of the concepts to practice.

New Title: Cancer Pain Management

Cancer Pain Management

©2007 McGraw Hill Publishers, Inc. Authors/Editors: Michael J. Fisch MD, MPH, FACP & Allen W. Burton MD

 

Introducing the first definitive guide to pain management in the cancer patient. This pioneering title is the first to provide in-depth coverage of all the interventional and medical strategies needed for effective cancer pain management. Logically organized, this immensely practical guide starts with general principles in cancer pain management, followed by management of specific cancer pain syndromes, unique issues, interventional techniques and other specialized approaches. Reflecting an approach to pain management developed at the prestigious M.D. Anderson Cancer Center, Cancer Pain Management addresses the full spectrum of cancer pain syndromes and reviews the selection and administration of various treatment options. Features: Discussions of the psychosocial aspects of pain and how to resume and retain function for specific pain--or disease-affected areas, such as in muscle tissue and bowels An incisive examination of all cancer pain syndromes Evidence-based pain management algorithms for each pain syndrome (included in each chapter) and synoptic tips for ensuring optimal patient care and pain relief Special issues in cancer pain management, such as ethical issues; dealing with regulatory concerns related to the prescription of opioids; chronic pain in the cured cancer patient; complementary and alternative approaches to cancer pain; intervention, spiritual, family and cultural issues; wound care; and procedural pain management Coverage of advanced technical protocols involved in interventional pain management Chapter-ending summary bullets and references that provide important opportunities for further study Helpful, practical appendices And more

Supporting Resource:

AJCC Cancer Staging Handbook 6th Ed. ©2002 Springer-Verlag New York, Inc.

This resource is used by physicians and health care professionals worldwide to facilitate the uniform description of neo-plastic diseases, the fully revised and updated resource brings together all currently available information on cancer staging at various anatomic sites and incorporates newly acquired knowledge on the etiology and pathology of cancer. Organized by disease site into 48 comprehensive chapters, it features much-anticipated, major revisions to the chapters on melanoma and breast cancer. Numerous new line drawings illustrate key anatomic sites throughout. The AJCC Cancer Staging Handbook remains the essential reference for oncologists, pathologists, surgeons, cancer registrars and medical professionals worldwide to assure that all are trained in the language of cancer staging.

New Title-Bioterrorism Sourcebook

Bioterrorism Sourcebook

2006 McGraw Hill Publishers, Inc.

Authors/Editors: Grey, Michael R., MD, MPH; Spaeth, Kenneth R., MD, MPH

This unique resource helps healthcare personnel provide expert, expeditious care to victims of biological, chemical, nuclear or radiologic events. Emphasizing tools for differentiating and treating conditions caused by biological and chemical agents, The Bioterrorism Sourcebook is the only one-stop source of step-by-step clinical guidance on diagnosis and treatment of bioterrorism-related conditions.

Concise and results-oriented, this resource features:

• Illustrations, charts, and synopses for fast categorization and identification of biological and chemical agents
• Tables of clinical manifestations that may result from contact with bioterror substances
• "Key Diagnostic Criteria" for all major biological, chemical and nuclear agents
• Essential findings for diagnosis
• Pathogenesis of major biological weapons
• Mechanisms of cellular and systemic injury
• Information on means of transmission, modes of dispersal and methods of exposure
• Risks for secondary infections and contamination
• Essential historical background on prior attacks and healthcare responses
• Discussion of use of the clinical setting in diagnosis
• Presenting actual patient management strategies for victims of biological, chemical and nuclear agents, The Bioterrorism Sourcebook is the one essential resource for a time we must prepare for--and hope never comes.

Supporting Resource:

Casarett and Doull's Toxicology: The Basic Science of Poisons

7th Ed. ©2008 McGraw-Hill Companies, Inc.

Long-established as the gold standard in the field, this resource is now available in a new Sixth Edition that equips you with an unsurpassed treatment of modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline.

Comprehensive and completely current, the new edition of Casarett and Doull’s Toxicology remains your best source for the latest breakthroughs in this fast-changing field.

AHFS Drug Information: What's New in April 2009

AHFS Drug Information
by Gerald K. McEvoy, PharmD and Elaine K. Snow, BS Pharm
American Society of Health-System Pharmacists (2009)

New Monographs:
None

 

Revised Monographs:

a1-Proteinase Inhibitor: a1-Proteinase inhibitor is a naturally occurring inhibitor of serine proteases such as neutrophil elastase; this enzyme aids in the proteolytic destruction of the alveolar walls and connective tissue framework of the lung parenchyma.

Antihemophilic Factor (Human): Antihemophilic factor (human) is a preparation of antihemophilic factor (blood coagulation factor VIII) prepared from pooled human venous plasma obtained from suitable whole-blood donors.

Antineoplastic Agents General Statement: The pharmacology of antineoplastic agents is complex. Most of the useful chemotherapeutic agents appear to exert their effects on enzymes or on substrates acted upon by enzyme systems that are involved in DNA synthesis or function. Therefore, cells in the mitotic cycle (i.e., proliferating cells) are the most susceptible to the drugs. Although the drugs have some degree of specificity for malignant cells as a result of differences in characteristics of these specific cells, other rapidly proliferating tissues such as bone marrow, gastrointestinal epithelium, skin, hair follicles, germinal epithelium of gonads, and embryonic structures may also be affected.

ACP Pier: What's New in April 2009

ACP PIER: Physicians' Information and Education Resource
American College of Physicians (2008)

PIER© is a collection of over 400 evidence summaries published by the American College of Physicians. Each module provides authoritative guidance to improve the quality of care. Topics are selected based upon prevalence in clinical settings. Evidence is then gathered by literature review and evaluated based on formal criteria. The level of evidence for each recommendation is displayed clearly within the application. This resource also includes topics in complementary and alternative medicine, ethical and legal issues and procedures.

NEW MODULE(S):

• Acetaminophen Poisoning
• Screening for Breast Cancer

AHFS DI® Essentials: What's New in April 2009

AHFS DI® Essentials

New Monographs:

None

Revised Monographs:

Abatacept: Biologic response modifier and disease-modifying antirheumatic drug (DMARD); a recombinant fusion protein.

Adalimumab: Biologic response modifier and disease-modifying antirheumatic drug (DMARD); a recombinant DNA-derived human immunoglobulin G1 (IgG1) monoclonal antibody specific for human tumor necrosis factor (TNF; TNF-a).

a1-Proteinase Inhibitor: A naturally occurring serine protease inhibitor.

Bismuth Salts: Antidiarrhea agent; antidyspepsia agent; internal deodorant.

Citrates: Alkalinizing agents.

Deferoxamine: Heavy metal antagonist; chelating agent for iron and aluminum.

Disopyramide: Antiarrhythmic agent (class IA).

Estradiol: Steroidal estrogen; a principal endogenous estrogen.

Estrogen-Progestin Combinations: Contraceptive combinations containing estrogenic and progestinic steroids.

Flucytosine: Antifungal; fluorinated pyrimidine analog structurally related to fluorouracil and floxuridine.

Fosphenytoin: Hydantoin-derivative anticonvulsant; prodrug of phenytoin.

Hydrocodone: Opiate agonist; phenanthrene derivative.

Isradipine: Calcium-channel blocking agent; dihydropyridine derivative.

Mycophenolate: Immunosuppressive agent.

Omeprazole: Acid- or proton-pump inhibitor; gastric antisecretory agent.

Phenytoin: Phenytoin is a hydantoin-derivative anticonvulsant.

Piperacillin/Tazobactam: Antibacterial; b-lactam antibiotic; fixed combination of piperacillin (an extended-spectrum penicillin) and tazobactam (a b-lactamase inhibitor).

Triptorelin: Antineoplastic agent; synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, gonadorelin); structurally related to leuprolide and goserelin.

New Title: Toxico-Terrorism

Toxico-Terrorism
Author: McFee, Robin B., DO, MPH, FACPM; Leikin, Jerrold B., MD, FABMT, FACEP, FACMT, FAACT, FACOEM
McGraw-Hill Publishers, Inc., ©2007

The emergency medicine expertise you need to prepare for, and manage, any type of bioterrorist attack!

Written by emergency room physicians for emergency room physicians, Toxico-terrorism covers every essential aspect of the emergency medical response to microbial, radiological and chemical agents of terrorism. You'll find lifesaving clinical strategies for the management of patients who have been exposed to a biologic, chemical or nuclear agent.

Features

-A logical, building-block organization filled with key tables and synoptic boxes
-Important coverage of pre-hospital and EMS issues
-Insights into the means of transmission, the modes of dispersal, and how secondary infection and/or contamination can occur
-Overview of bioterror-specific signs and symptoms
-A section on emergency department preparedness that reviews critical topics such as nursing triage, hospital/facility security, pharmacy preparedness and hospital staff issues
-Current information on labs, microscopy and radiology
-Key diagnostic criteria for all agents
-Thorough coverage of treatment strategies for all agents discussed
-Infection control modalities
-Survey of prophylaxis strategies
-Valuable section on public health considerations

Supporting Resource: Emergency Medicine Procedures (©2004 Pearson Education, Inc.)

This title provides a detailed, step-by-step, approach to procedures that are performed in
the emergency department. Not meant as a comprehensive reference, this is an
easy to use, clinically useful procedure book that is a must in every emergency
department.

Detailed Drug Information for the Consumer: What's New in March 2009

Detailed Drug Information for the Consumer™
by Thomson Healthcare, Inc.
Thomson Healthcare, Inc., (2008)

NEW MONOGRAPHS:

• BENZTROPINE (Injection route)
• BENZTROPINE (Oral route)
• BIPERIDEN (Oral route) 
• DIGOXIN (Injection route)
• DIGOXIN (Oral route) 
• ETHOSUXIMIDE (Oral route)
• ETHOTOIN (Oral route) 
• FOSPHENYTOIN (Injection route) 
• METHSUXIMIDE (Oral route)
• PHENYTOIN (Injection route)
• TEMOZOLOMIDE (Intravenous route)
• TRIHEXYPHENIDYL (Oral route)
• TRYPAN BLUE (Intraocular route)
• VALPROATE SODIUM (Intravenous route)

DrugPoints® System: What's New in March, 2009

DrugPoints® System
by Thomson Healthcare, Inc.
Thomson Healthcare, Inc., (2008)

Rather than giving you too little or too much information, DrugPoints® System gives you direct access to the exact level of drug information you need to do your job. This evidence-based resource helps healthcare professionals prescribe, administer and monitor drugs safely and efficiently. Contains more than 1,400 concise and unbiased synopses on drugs.

New Monographs:

• Degarelix Acetate